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| Knowhow offering | |
| Title | New drug target & promising chemical starting point for treating cancer - PIP3 Antagonists |
| Knowhow is available for | A new therapeutic strategy that identifies a new drug target and development of various promising small molecules that show promising results in animal testing to be further developed into drugs for treatment of cancer. |
| Summary | Our technology looks at identifying a new strategy and potential drug molecules that target lipid-protein interactions (PIP3/protein binding) as a therapeutic tactic. We have also developed promising chemical leads (small molecule antagonists for PIP3/protein binding) – which inhibit cancer cell survival, resulting in significant antitumor activity in vivo as well as a set of small molecule non-lipid antagonists of lipid-protein interactions, which can be used to design specific drugs |
| Advantages | • Can selectively inhibit PIP3-mediated signaling • Found to be able to target a wide range of PIP3-dependent signaling events in vitro • Significant anti-tumour activity in vivo • Exhibit improved activity /PH domain selectivity compared to previously identified antagonists • Promising chemical starting points that have been optimized, that have undergone successful animal trials |
| Knowhow is listed under following categories | |
| Knowhow from | CSIR-NCL, Pune |
| Scientific/ engineering subject areas | Life sciences/ biosciences & engineering ; Chemical sciences & engineering |
| Investor interest categories | Materials Technology including Nanotechnology ; Biotechnology/ Biomedical/ Health Technologies |
| Industries | Pharmaceuticals, Bulk Drugs, Formulations ; Others |
| Customer categories and nature of business | Businesses and other industries (B2B) ; Others |
| Technology readiness levels | TRL A : Technology concept formulated |
Year of development | 2010 |
| Whether patents are part of this offering ? | Yes |
| Related documents: | |
| Write- ups and marketing documents | |
| Database reference | |
| Database record number | 20130929104712 |
| Date of upload | 30 / Sep / 2013 |
| Date of update | 4 / Oct / 2013 |
| URL to site when communicating about this knowhow | http://nclinnovations.org/khdb/viewrecord.php?recordno=20130929104712 |
| Request for this technology | Click here for Request Form |
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